Assembly and secretion of hepatic very-low-density lipoprotein
نویسندگان
چکیده
منابع مشابه
Assembly and secretion of hepatic very-low-density lipoprotein.
In contrast to water-soluble fuels such as glucose or ketone bodies, the use of lipids as an energy source for tissues has required the development of complex structures for their transport through the aqueous plasma. In the case of endogenously synthesized triacylglycerol this is achieved by the assembly and secretion of hepatic VLDL which provides the necessary stability in an aqueous medium....
متن کاملThe enzymology of hepatic very-low-density lipoprotein assembly.
The synthesis and export of triacylglycerol (TAG) by the liver provides mammals with an efficient means of transporting a powerful source of energy either for storage in adipose tissue or for utilization, predominantly by muscle tissue. On a molar basis, the transport of large quantities of energy as TAG may be achieved at relatively low concentrations of TAG in the blood plasma. Similar amount...
متن کاملSynthesis and function of hepatic very-low-density lipoprotein.
Most of the triacylglycerol (TAG) utilized for the assembly of very-low-density lipoprotein (VLDL) in the secretory apparatus of the hepatocyte is mobilized by lipolysis of the cytosolic TAG pool, followed by re-esterification. The lipases involved include arylacetamide deacetylase and/or triacylglycerol hydrolase. Some of the re-esterified products of lipolysis gain access to an apolipoprotein...
متن کاملApolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion
Apolipoprotein B (apoB) is the main protein component of very low density lipoprotein (VLDL) and is necessary for the assembly and secretion of these triglyceride (TG)-rich particles. Following release from the liver, VLDL is converted to low density lipoprotein (LDL) in the plasma and increased production of VLDL can therefore play a detrimental role in cardiovascular disease. Increasing evide...
متن کاملSodium sulfite promotes the assembly and secretion of very low-density lipoprotein in HL-7702 hepatocytes
This study investigated the effects of Na2SO3 on the fat metabolism in human normal diploid HL-7702 (referred as L-02) hepatocytes. After 24 h and 48 h, treatment with different concentrations of Na2SO3, the intra and extra-hepatocellular triglyceride (TG) contents of L-02 were determined using chemical-enzymatic method. The contents of very low-density lipoprotein (VLDL) and apolipoprotein B10...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1990
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2680001